Cephalosporin is very much crucial to fight against contagious diseases especially for life threatening (serious) infections. But dedicated manufacturing facility is required to produce cephalosporin in order to prevent any cross contamination. Cephalosporin Plant of Pharmasia is a dedicated manufacturing facility, producing both oral and other dosage forms. It has state-of-the art production facilities with the largest production capacity for Cephalosporin products. High quality standards in compliance with current international cGMP regulations are maintained throughout the manufacturing process and product quality control.
Pharmasia is producing and enriching its portfolios by adding new generations and derivatives by considering the patients benefit in the day going on. According to WHO cGMP, cross contamination between beta lactam and non-beta lactam products should be avoided and cross contamination between penicillin beta lactam and non-penicillin beta lactum should be avoided. Consider the manufacturing guidelines, Pharmasia makes its Cephalosporin Separate manufacturing facility means separate building, separate air handling units (HVAC system), separate equipment, separate utilities and separate staff.
The main features of the dedicated Cephalosporin Production Building (CPB) are as follows:
3 layers building : With a focus to prevent cross contamination the most modern three-layer building concept is adopted in this building.
Level–1: A 10 feet height Manufacturing Area dedicated for production operations, Level–2: A 6 feet height Service Deck dedicated for service lines and ducting’s.
Level–3: A 12 feet height Energy Deck dedicated for service and utility machinery.
Clean Corridors, Walls, Floors & Ceiling : One clean corridor of 6 feet width for easy uninterrupted personnel and material movement. Walls are Plaster finish on high-quality concrete blocks. The finish is smooth with shed-free cleanable plastic painting. Floor of the facilities are self-leveling Epoxy (thickness – 3 mm) painted floor provides a durable and readily cleanable surface resistance to the chemicals with which it is likely to come into contact.The ceiling is made of sandwich panel, 42 mm thick walk on type to take middle span mobile load of 120 kg, surface metal 0.5 mm thick with protective film and exterior shall 0.5 mm thick galvanized sheet. Inside the metal sheet there is self-extinguished polyurethane foam of density 38-40 kg/m3 and thermal conductivity is 0.44 Kcal/m2Hr0C. Smooth & easily cleanable. All ceiling fixtures such as light fittings, air outlets and returns, sprinkler heads, dust extraction system etc are designed as such that assures easy cleaning and minimize the potential for accumulation of dust. Metal windows are double flushed with both side of the wall with shed-free doccu-painting. Double glass (thickness 5 mm) flushed with both sides of the windows, inert Nitrogen gas between the glasses.