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Flugard

Flugard

Generic Name : ( )

Therapeutic Group : Antifungal

Overview:

Fluconazole is used to prevent and treat a variety of fungal and yeast infections. It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus.

Presentation

Capsule           :           150 & 50 mg

Preparation:

Flugard 50 mg capsule: Each capsule contains Fluconazole USP 50 mg.
Flugard 150 mg capsule: Each capsule contains Fluconazole USP 150 mg.

Description:

Fluconazole is the first of a new subclass of synthetic triazole antifungal agent which acts by inhibition of the ergosterol component of the fungal cell membrane. It is active against a broad spectrum of fungal pathogens and is available for oral use.

Indications:

Acute or recurrent vaginal candidiasis, mucosal candidiasis e.g. oropharyngeal, oesophageal, bronchopulmonary, mucocutaneous, denture, sore mouth, tinea pedis, tinea corporis, tinea cruris, tinea versicolor and dermal candida infection. Systemic candidiasis including candidaemia, disseminated candidiasis and other forms of candidial infection. Cryptococcosis, cryptococcal meningitis and infections of other sites (pulmonary and cutaneous). For prevention of fungal infections in immunocompromised patients e.g. neutropenic cancer patients.

Dosage & Administrations:

Adult: Acute and recurrent vaginal candidiasis and candidal balanitis: Orally a single dose 150 mg, Mucosal candidiasis (except vaginal): Orally 50 mg daily (100 mg daily in a single dose in usually difficult infection) for 7-14 days. Oropharyngeal candidiasis for maximum 14 days, in atropic oral candidiasis with denture for 14 days, in oesophagitis and candiduria for 14-30 days. Tinea pedis, corporis, cruris, pityriasis versicolor and dermal candidiasis: Orally 50 mg daily for 2-4 weeks (upto 6 weeks in tinea pedis) maximum duration of treatment is 6 weeks. Systemic candidiasis and cryptococcal infections (including meningitis): Orally 400 mg initially daily then 200 mg daily and continue treatment according to response. Prevention of fungal infections in immunocompromised patients- 3-12 mg/kg every 72 hours up to 2 weeks old 3-12 mg/kg every 48 hours up to 2-4 weeks old

Warning & Precautions:

Caution should be taken in renal impairment, pregnancy and breast-feeding and the raised liver enzymes.

Side Effects:

Therapy with Fluconazole is well tolerated. The common adverse effects are nausea. abdominal pain, vomiting, diarrhea, headache and skin rash.

Drug Interactions:

Rifampicin reduces plasma concentration of Fluconazole. Fluconazole enhances the effect of nicoumalone, warfarin and phenytoin. It also increases the plasma concentration of sulphonylureas & theophlline.

Use in Special Groups:

Use in pregnancy: Fluconazole should be used in pregnancy only if the potential benefit justifies the possible risk to the fetus.
Use in lactation : Fluconazole is secreted in human milk at concentrations similar to plasma. Therefore, the use of Flouconazole in nursing mother is not recommended.

Contraindications:

Fluconazole should not be used in patients with known hypersensitivity to fluconazole or to related azole compounds.

Storage Conditions:

Store at temperature not exceeding 300C.

Commercial Pack:

Flugard 50 mg capsule: Box containing 30's capsules in alu-alu blister pack.
Flugard 150 mg capsule: Box containing 12's capsules in alu-alu blister pack.